VenatoRx Pharmaceuticals to present at ASM Microbe in the New Agents Discovery Summary Session and Emerging Tech Talks

The company will also present five posters featuring its lead clinical antibacterial candidate, cefepime/VNRX-5133

Malvern, PA, May 31, 2018 – VenatoRx Pharmaceuticals will feature its lead clinical antibacterial candidate, cefepime/VNRX-5133, at ASM Microbe which is taking place in Atlanta, GA from June 7-11, 2018.

VNRX-5133 is a new-generation beta-lactamase inhibitor (BLI) with unique broad-spectrum activity, covering both serine- and metallo-beta-lactamases. VenatoRx is developing VNRX-5133 in a fixed combination with the 4^th generation cephalosporin, cefepime. VenatoRx believes that cefepime/VNRX-5133 has the potential to become a valuable treatment option for infections caused by multi-drug resistant (MDR) gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa, suspected polymicrobial infections caused by both gram-negative and gram-positive pathogens, and bioterror pathogens such as Burkholderia spp. and Salmonella spp.

This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201300019C, and Wellcome Trust under Award No. 360G-Wellcome-101999/Z/13/Z.

VenatoRx’s presentations at ASM Microbe will take place as follows:

New Agents Discovery Summary Session: Early New Antimicrobial Agents

This session will highlight the discovery of new antimicrobial agents. VenatoRx’s presentation entitled, “VNRX-5133: A Selective, Potent and Broad Spectrum Inhibitor of both Serine- and Metallo-Beta-Lactamases” will be presented by Founder and Senior Vice President, Biology and Grants Development, Daniel C. Pevear, Ph.D., on Friday, June 8, 2018 at 10:15am in Building A, Level 4, A411 and Lounge and Learn 1.

Emerging Tech Talks

This session will feature presentations from industry representatives who will highlight the field’s latest technologies to hit the market as well as those on the horizon. VenatoRx’s presentation will take place on Saturday, June 9, 2018 at 11:00am on the Exhibit Hall Floor in Booth #2422.

Poster Presentations

Poster presentations featuring VenatoRx’s lead clinical antibacterial candidate, cefepime/VNRX-5133, will be held on Friday, June 8, 2018 from 11:00am – 1:00pm in the Exhibit and Poster Hall, Building B, Halls B2-B5:

Session# 42 – CPHM02 Antimicrobial Susceptibility Testing: Gram-Negative Bacteria

Session# 62 – AAR08 – New Antimicrobial Agents and New Research Technologies: New b-Lactamase Inhibitors and Inhibitor Combinations

Poster: FRIDAY – 609 – In vitro activity of cefepime in combination with VNRX-5133 against gram-negative UTI isolates. M. Hackel, D. Pevear and D. Sahm.
Poster: FRIDAY – 610 – Cefepime/VNRX-5133 retains potent activity against KPC variants responsible for recent clinical treatment failures of Ceftazidime/Avibactam in Klebsiella Pneumoniae. C. Myers, D. Daigle, N. Kurepina, B. Kreiswirth, R. Shields, C. Clancy, M-H. Nguyen and D. Pevear.
Poster: FRIDAY – 611 – Evaluation of the impact of variation in standard testing parameters on the activity of cefepime in combination with VNRX-5133. S. Hawser, S. Magnet, I. Morrissey and S. Cusick.
Poster: FRIDAY – 612 – Efficacy of cefepime combined with VNRX-5133, a novel broad-spectrum ?-lactamase inhibitor, against a cephalosporin-resistant ESBL E. coli in a murine UTI model. W. Weiss, M. Pulse, P. Nguyen, D. Valtierra, K. Peterson, K. Carter, D. Pevear and C. Burns.

About VenatoRx Pharmaceuticals, Inc.

Led by a world-class team of pharmaceutical veterans, VenatoRx is a private pharmaceutical company that is developing a new wave of antibiotic products to combat the increasing threat of carbapenem antibiotic resistance. VenatoRx’s lead product, VNRX-5133, is an injectable broad-spectrum beta-lactamase inhibitor (BLI) that directly inhibits all four Ambler classes of beta-lactamases. Early clinical studies of cefepime/VNRX-5133 have been completed and VenatoRx plans to start Phase 3 pivotal trials in the second half of 2018. In addition, VenatoRx has a broad pipeline of preclinical programs, including a broad-spectrum orally bioavailable BLI, and a novel class of Penicillin-Binding Protein (PBP) inhibitors that are impervious to beta-lactamase-driven resistance. For more information, please visit www.venatorx.com.

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Michael N. Dudley, Pharm.D.

President and Chief Executive Officer
Qpex Biopharma, Inc.

Dr. Dudley has over 30 years of experience in antiinfective drug research, development, and commercialization. In 2018, he co-founded Qpex Biopharma which raised $33M in Series A financing and acquired the preclinical infectious disease programs from The Medicines Company. He has overseen the development and regulatory approval of 3 antibiotics, most recently a beta-lactamase inhibitor combination product from a new chemical class (vaborbactam) discovered in the company laboratories. The antibiotic product Vabomere™ advanced from discovery to FDA approval in 2017 in less than 8 years. He lead the negotiation for multiple contracts from public-private partnerships (e.g., BARDA of the US Government; Innovative Medicines Initiative for the EU) for a combined total of over $190 million funding to advance antimicrobial agents in development in the US and Europe. Prior to co-founding Qpex, he was Chief Scientific Officer and co-founder of Rempex Pharmaceuticals that was acquired by the Medicines Company (MDCO) in 2013, where he remained as the co-leader of the Infectious Disease Business Unit of MDCO. Prior to Rempex, he held VP/SVP/CSO positions of increasing responsibility at the biotech companies Mpex Pharmaceuticals (acquired by Aptalis in 2011), Diversa Corporation, and Microcide Pharmaceuticals. Prior to his career in pharmaceutical industry, he held full-time academic appointments that included Professor of Pharmacy and Chairman of the Department of Pharmacy Practice at the University of Rhode Island College of Pharmacy (URI), and Adjunct Professor of Medicine, Brown University School of Medicine at Roger Williams Medical Center in Providence, RI. As an academic researcher, he conducted preclinical and clinical research in antibacterial, antifungal, and antiviral agents, including pioneering work on PK-PD approaches for several classes of antiinfectives. Dr. Dudley has published over 130 scientific papers and book chapters describing the evaluation and clinical use of antiinfective agents and treatment of infectious diseases. He has served as an invited speaker at several FDA and EMA workshops, international meetings on infectious diseases, and advisor to several companies. He has served as an Editor for the journal Antimicrobial Agents and Chemotherapy and numerous other editorial and advisory boards. He completed undergraduate work at Pepperdine University and his Doctor of Pharmacy (PharmD) from the University of California San Francisco (UCSF), completed at residency at UCSF, and a fellowship in infectious diseases at Hartford Hospital.

VenatoRx Pharmaceuticals to present at ASM Microbe in the New Agents Discovery Summary Session and Emerging Tech Talks

VenatoRx Pharmaceuticals to present at ASM Microbe in the New Agents Discovery Summary Session and Emerging Tech Talks

René Russo, PharmD, BCPS

René Russo, PharmD, BCPS

Roger J. Pomerantz, M.D., F.A.C.P.

Christine Ann Miller

Graham G. Lumsden

Marco Taglietti, M.D.

Ankit Mahadevia

Jeffrey Stein, Ph.D.

Evan Loh, M.D.

Michael Dunne, M.D

Ciara Kennedy, Ph.D.

Ted Schroeder

Kevin Finney

Manos Perros, Ph.D.

David Roblin

Stephen Conafay

Christopher J. Burns, Ph.D.

Michael N. Dudley, Pharm.D.

Ramani Varanasi

Corey Fishman

Felix Faupel

Adrian Nivoliez