Cidara Therapeutics to Present New Data for Rezafungin and Influenza AVCs at the 21st ICHS Symposium

SAN DIEGO, Feb. 11, 2021 (GLOBE NEWSWIRE) — Cidara Therapeutics, Inc. (Nasdaq: CDTX), a biotechnology company developing long-acting therapeutics designed to transform the standard of care for patients facing serious fungal or viral infections, today announced an oral presentation and four poster presentations at the 21^st International Immunocompromised Host Society (ICHS) Symposium on Infections in the Immunocompromised Host, taking place virtually Feb. 17-19, 2021.

Cidara will share new findings related to rezafungin, its novel once-weekly echinocandin in Phase 3 trials for the treatment and prevention of serious fungal infections, in three poster presentations. Additionally, an oral overview of rezafungin by Taylor Sandison, M.D., M.P.H., chief medical officer of Cidara will be part of the symposium proceedings. Details are as follows:

Oral Presentation:

Title: Rezafungin: Evidence and Experience to Date
Presenter: Taylor Sandison, M.D., M.P.H., chief medical officer, Cidara Therapeutics
Session: Industry Symposia: New anti-fungals
Date and Time: Feb. 19, 2021 at 12:40 – 1:00 p.m. AEDT/Feb. 18, 2021 at 8:40 – 9:00 p.m. EST

Poster Presentations:

Title: Safety and Efficacy of Rezafungin in Immunocompromised Patients: Analysis of Outcomes from the Phase 2 STRIVE Trial of Rezafungin for Treatment of Candidemia and Invasive Candidiasis
Presenter: Taylor Sandison, M.D., M.P.H., chief medical officer, Cidara Therapeutics
A live Q&A session will take place on Feb. 18, 2021 at 1:00 – 2:00 p.m. AEDT/Feb. 17, 2021 at 9:00 – 10:00 p.m. EST.

Title: Efficacy and Safety by Renal Function in the Phase 2 STRIVE Trial of Rezafungin in Treatment of Candidemia and Invasive Candidiasis
Presenter: Shawn Flanagan, Ph.D., vice president clinical pharmacology & early development, Cidara Therapeutics
A live Q&A session will take place on Feb. 18, 2021 at 1:00 – 2:00 p.m. AEDT/Feb. 17, 2021 at 9:00 – 10:00 p.m. EST.

Title: Fungal Eradication with Extended Rezafungin Treatment in a Murine Model of Pneumocystis Pneumonia
Presenter: Taylor Sandison, M.D., M.P.H., chief medical officer, Cidara Therapeutics

Preclinical data from the antiviral conjugate (AVC) candidate, CD377 for prevention and treatment of influenza, will also be highlighted in one poster presentation. Details of the presentation are as follows:

Poster Presentation:

Title: Efficacy of CD377, a Novel Antiviral Fc-Conjugate, Against Influenza in a Lethal Mouse Model of Severe Combined Immunodeficiency (SCID)
Presenter: James Levin, Ph.D., senior director of preclinical development, Cidara Therapeutics
A live Q&A session will take place on Feb. 18, 2021 at 1:00 – 2:00 p.m. AEDT/Feb. 17, 2021 at 9:00 – 10:00 p.m. EST.

Copies of the abstracts will be made available on the Publications section of the Cidara website.

About Rezafungin
Rezafungin is a novel once-weekly echinocandin being developed for both the treatment and prevention of serious fungal infections, such as candidemia and invasive candidiasis. The structure and properties of rezafungin are specifically designed to improve upon a clinically validated mechanism intended to enhance its efficacy and safety potential for patients. Cidara is currently conducting a Phase 3 clinical trial with rezafungin for the first-line treatment of candidemia and/or invasive candidiasis (ReSTORE trial) and a second Phase 3 clinical trial of once-weekly rezafungin for the prevention of invasive fungal disease in patients undergoing allogeneic blood and marrow transplantation (ReSPECT trial).

About Cloudbreak AVCs
Cidara is developing a new generation of immunotherapeutic antivirals from its Cloudbreak antiviral platform that couple potent antivirals to a human antibody fragment. These long-acting, antiviral conjugates (AVCs) directly inhibit viral proliferation while simultaneously engaging the immune system. AVCs are initially being studied for the prevention and treatment of seasonal and pandemic influenza, with the potential to deliver universal protection for an entire flu season with a single dose. Cidara is also advancing preclinical and discovery AVC programs to target other life-threatening viruses, such as RSV, HIV and CoV, including COVID-19.

About Cidara Therapeutics
Cidara is developing long-acting therapeutics designed to transform the standard of care for patients facing serious fungal or viral infections. The Company’s portfolio is comprised of its lead antifungal candidate, rezafungin, in addition to antiviral conjugates (AVCs) for the prevention and treatment of influenza and other viral diseases from Cidara’s proprietary Cloudbreak® antiviral platform. Cidara is headquartered in San Diego, California. For more information, please visit www.cidara.com.

INVESTOR CONTACT:
Brian Ritchie
LifeSci Advisors
(212) 915-2578
britchie@lifesciadvisors.com

MEDIA CONTACT:
Karen O’Shea, Ph.D.
LifeSci Communications
(929) 469-3860
koshea@lifescicomms.com

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Michael N. Dudley, Pharm.D.

President and Chief Executive Officer
Qpex Biopharma, Inc.

Dr. Dudley has over 30 years of experience in antiinfective drug research, development, and commercialization. In 2018, he co-founded Qpex Biopharma which raised $33M in Series A financing and acquired the preclinical infectious disease programs from The Medicines Company. He has overseen the development and regulatory approval of 3 antibiotics, most recently a beta-lactamase inhibitor combination product from a new chemical class (vaborbactam) discovered in the company laboratories. The antibiotic product Vabomere™ advanced from discovery to FDA approval in 2017 in less than 8 years. He lead the negotiation for multiple contracts from public-private partnerships (e.g., BARDA of the US Government; Innovative Medicines Initiative for the EU) for a combined total of over $190 million funding to advance antimicrobial agents in development in the US and Europe. Prior to co-founding Qpex, he was Chief Scientific Officer and co-founder of Rempex Pharmaceuticals that was acquired by the Medicines Company (MDCO) in 2013, where he remained as the co-leader of the Infectious Disease Business Unit of MDCO. Prior to Rempex, he held VP/SVP/CSO positions of increasing responsibility at the biotech companies Mpex Pharmaceuticals (acquired by Aptalis in 2011), Diversa Corporation, and Microcide Pharmaceuticals. Prior to his career in pharmaceutical industry, he held full-time academic appointments that included Professor of Pharmacy and Chairman of the Department of Pharmacy Practice at the University of Rhode Island College of Pharmacy (URI), and Adjunct Professor of Medicine, Brown University School of Medicine at Roger Williams Medical Center in Providence, RI. As an academic researcher, he conducted preclinical and clinical research in antibacterial, antifungal, and antiviral agents, including pioneering work on PK-PD approaches for several classes of antiinfectives. Dr. Dudley has published over 130 scientific papers and book chapters describing the evaluation and clinical use of antiinfective agents and treatment of infectious diseases. He has served as an invited speaker at several FDA and EMA workshops, international meetings on infectious diseases, and advisor to several companies. He has served as an Editor for the journal Antimicrobial Agents and Chemotherapy and numerous other editorial and advisory boards. He completed undergraduate work at Pepperdine University and his Doctor of Pharmacy (PharmD) from the University of California San Francisco (UCSF), completed at residency at UCSF, and a fellowship in infectious diseases at Hartford Hospital.

Cidara Therapeutics to Present New Data for Rezafungin and Influenza AVCs at the 21st ICHS Symposium

René Russo, PharmD, BCPS

René Russo, PharmD, BCPS

Roger J. Pomerantz, M.D., F.A.C.P.

Christine Ann Miller

Graham G. Lumsden

Marco Taglietti, M.D.

Ankit Mahadevia

Jeffrey Stein, Ph.D.

Evan Loh, M.D.

Michael Dunne, M.D

Ciara Kennedy, Ph.D.

Ted Schroeder

Kevin Finney

Manos Perros, Ph.D.

David Roblin

Stephen Conafay

Christopher J. Burns, Ph.D.

Michael N. Dudley, Pharm.D.

Ramani Varanasi

Corey Fishman

Felix Faupel

Adrian Nivoliez